解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIM:This study was conducted to find out the optimal vitamin D cutoff point in predicting activity of RA disease. MATERIALS AND METHODS:One hundred and two rheumatoid arthritis Saudi patients of both genders were recruited in this study. Vitamin D as 25-hydroxy-vitamin D [25(OH)D] was measured and serum level less tha...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/260725
更新日期:2015-01-01 00:00:00
abstract:AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/616541
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we consecutively...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/302649
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D suppleme...
journal_title:Disease markers
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/918968
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/648670
更新日期:2015-01-01 00:00:00
abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/818570
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/786708
更新日期:2015-01-01 00:00:00
abstract::High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The independent contributions of CRF and PA to metabolic disease risk factors are unknown. We tested the hypothesis that runners who run consistently >50 km/wk and/or >...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/806418
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/591454
更新日期:2015-01-01 00:00:00
abstract::High recurrence rate is one representative characteristic of bladder cancer. Intravesical therapy after transurethral resection is often performed in patients with nonmuscle invasive bladder cancer (NMIBC) to prevent recurrence. Bacillus Calmette-Guérin (BCG) and several anticancer/antibiotic agents, such as mitomycin...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/857416
更新日期:2015-01-01 00:00:00
abstract::Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the prese...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/727401
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/157812
更新日期:2015-01-01 00:00:00
abstract::This study evaluated the in vitro sensitivity of paired Leishmania braziliensis samples isolated from the same patient before pentavalent antimonial treatment (Sample A) and after treatment failure or cutaneous leishmaniasis reactivation (Sample B) in patients undergoing intralesional administration or injections (5 m...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943236
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/597570
更新日期:2015-01-01 00:00:00
abstract::As the most common neoplasm arising from the kidney, renal cell carcinoma (RCC) continues to have a significant impact on global health. Conventional cross-sectional imaging has always served an important role in the staging of RCC. However, with recent advances in imaging techniques and postprocessing analysis, magne...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/648495
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 ye...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/947432
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less eff...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/678246
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. METHODS:Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels,...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/690853
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/315824
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Microarray technology shows great potential but previous studies were limited by small number of samples in the colorectal cancer (CRC) research. The aims of this study are to investigate gene expression profile of CRCs by pooling cDNA microarrays using PAM, ANN, and decision trees (CART and C5.0). METHODS:...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2014/634123
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The associations between the Fractalkine receptor (CX3CR1) gene T280M (rs3732378) and V249I (rs3732379) polymorphisms and atherosclerosis (AS) risk are conflicting. The aim of this meta-analysis was undertaken to assess their associations. METHODS:PubMed, Embase, Web of Science, Medline, Cochrane database, ...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2014/913678
更新日期:2014-01-01 00:00:00
abstract::Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC proliferation and LTCCα 1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/237067
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:A novel swine-origin influenza A H1N1 virus (S-OIV) caused human infection and acute respiratory illness in 2009, resulting in an influenza pandemic. OBJECTIVES:This study characterized the immune responses of S-OIV infection in pediatric patients at risk of pulmonary complications. METHODS:All enrolled pe...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/195453
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/485687
更新日期:2014-01-01 00:00:00
abstract::Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/351863
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/912182
更新日期:2014-01-01 00:00:00
abstract::Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/238197
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 serone...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/480201
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS:We performed an immunohist...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/494581
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. METHODS:In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/534534
更新日期:2014-01-01 00:00:00
abstract::Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/634289
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Liver cirrhosis (LC) is the final stage of most of chronic liver diseases and is almost caused by chronic hepatitis B (CHB) in China. Liver biopsy is the reference method for the evaluation of liver cirrhosis. However, it is an invasive procedure with inherent risk. The aim of this study was to construct a n...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/127962
更新日期:2013-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120957
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an addi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/970736
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130974
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The purpose of the present study is to explore the correlation between nuclear expression of cyclin-dependent kinase inhibitor 1B (p27) and clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient survival. METHODS:Immunohistochemistry was used to examine the expression of p27 in 130 p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/251209
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:We investigated the relationship between NT-pro-BNP, glomerular filtration rate (GFR), and all-cause mortality rates in a cohort of older people discharged from an internal medicine unit after admission for dyspnoea. PATIENTS AND METHODS:NT-pro-BNP was evaluated in serum samples of 134 patients aged 80 ± 6 ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/687467
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM). DESIGN:PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodonti...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/803240
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma. METHODS:Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohist...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/416870
更新日期:2013-01-01 00:00:00